書誌事項
- タイトル別名
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- Analysis of Actin Protein Dynamics at the Protrusion Process of Cell Movement
- サイボウ ウンドウ ノ トッシュツ カテイ ニ オケル アクチンダイナミクス カイセキ
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抄録
Actin, a cytoskeletal protein, gathers and polymerizes under the cell membrane to mediate protrusion of the cell membrane. Therefore, actin participates greatly in cell movement. To quantitatively evaluate actin's dynamics during cell protrusion, movements of actin-labeled cells were observed under a confocal laser scanning microscopy, and time-lapse images were obtained. Image analysis of the orientation of actin stress fibers revealed dynamic formation of a meshwork of stress fibers in the protrusion structure at the leading edge of the motile cell. In addition, a number of immobile spots such as focal adhesions were observed adjacent to the dynamic meshwork of stress fibers. The distribution and the time between appearance and disappearance of each spot were analyzed. The results suggest that immobile spots close to the centroid of the cell play a crucial role in providing anchorage and driving cell movement.
収録刊行物
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- 電気学会論文誌Ｃ（電子・情報・システム部門誌）
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電気学会論文誌Ｃ（電子・情報・システム部門誌） 134 (2), 177-182, 2014
一般社団法人 電気学会
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詳細情報 詳細情報について
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- CRID
- 1390001204608571264
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- NII論文ID
- 130003391703
- 40019981174
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- NII書誌ID
- AN10065950
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- ISSN
- 13488155
- 03854221
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- NDL書誌ID
- 025257525
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可