Estimation of Visceral Fat and Fatty Liver Disease Using Ultrasound in Patients with Diabetes

DOI 機関リポジトリ HANDLE Web Site PubMed 被引用文献1件 参考文献15件
  • Onitsuka Yasunori
    Onitsuka Internal Medicine and Gastroenterology Clinic, Japan
  • Takeshima Fuminao
    Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Japan
  • Ichikawa Tatsuki
    Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Japan
  • Kohno Shigeru
    The Second Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Japan
  • Nakao Kazuhiko
    Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Japan

この論文をさがす

抄録

Objective Fatty liver disease is the most commonly encountered form of chronic liver dysfunction in routine medical care and is closely associated with type 2 diabetes. We aimed to elucidate how the use of new medications affects the incidence of fatty liver disease and amount of visceral fat, both of which are associated with diabetes.<br> Methods Abdominal ultrasonography was performed to assess the preperitoneal fat thickness (PFT) and presence of fatty liver. The PFT, body mass index (BMI) and waist circumference were used to investigate the rate and development of fatty liver disease in each group. A multivariate analysis with multiple logistic regression was performed using the PFT and presence of fatty liver disease as dependent variables.<br> Patients We evaluated 202 patients treated at the Onitsuka Clinic. The subjects were divided into three subgroups (non-diabetic and diabetic with or without treatment with antidiabetic medications).<br> Results Positive correlations between the PFT, BMI, and waist circumference were observed. No increases in the prevalence of fatty liver disease were observed in the medicated diabetic group, even when the PFT levels were high. A multivariate analysis with multiple logistic regression revealed that visceral fat accumulation was inhibited in women and those taking statins or thiazolidines and aggravated in men and those with obesity or an increased waist circumference. Obesity was an aggravating factor for fatty liver disease, and biguanides were useful as counteractants.<br> Conclusion Measuring the PFT is effective for screening metabolic syndrome and evaluating diabetes, dyslipidemia and hypertension associated with fatty liver disease. Clinically, fatty liver progression to non-alcoholic steatohepatitis (NASH) may be prevented by tackling obesity and administering appropriate medications.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 53 (6), 545-553, 2014

    一般社団法人 日本内科学会

被引用文献 (1)*注記

もっと見る

参考文献 (15)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ