Severe Enteropathy Caused by α-Heavy Chain Disease Lacking Detectable M-proteins
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- Kurimoto Miwa
- Department of Hematology/Oncology, Wakayama Medical University, Japan
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- Sonoki Takashi
- Department of Hematology/Oncology, Wakayama Medical University, Japan
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- Nakamura Yasushi
- Department of Laboratory Medicine, Wakayama Medical University, Japan
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- Yamamoto Yasuhide
- The Second Department of Internal Medicine, Wakayama Medical University, Japan
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- Maeda Yoshimasa
- The Second Department of Internal Medicine, Wakayama Medical University, Japan
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- Kuriyama Kodai
- Department of Hematology/Oncology, Wakayama Medical University, Japan
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- Mushino Toshiki
- Department of Hematology/Oncology, Wakayama Medical University, Japan
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- Hosoi Hiroki
- Department of Hematology/Oncology, Wakayama Medical University, Japan
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- Murata Shogo
- Department of Hematology/Oncology, Wakayama Medical University, Japan
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- Shimanuki Masaya
- Department of Hematology/Oncology, Wakayama Medical University, Japan
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- Hatanaka Kazuo
- Department of Hematology/Oncology, Wakayama Medical University, Japan
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- Hanaoka Nobuyoshi
- Department of Hematology/Oncology, Wakayama Medical University, Japan
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- Kato Jun
- The Second Department of Internal Medicine, Wakayama Medical University, Japan
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- Nakakuma Hideki
- Department of Hematology/Oncology, Wakayama Medical University, Japan
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抄録
A 57-year-old Japanese man was admitted to our hospital with diarrhea, weight loss and malabsorption. Due to a high serum IgA level, we suspected α-heavy chain disease (α-HCD). However, no monoclonal IgA was detected on protein electrophoresis or immunofixation. Immunohistochemical staining of intestinal biopsy specimens showed proliferation of CD138+IgA+ cells, compatible with a diagnosis of α-HCD. Most α-HCD patients exhibit M-proteins in the serum on electrophoresis or immunoelectrophoresis; however, some patients lack detectable M-proteins, similar to our patient. Therefore, when α-HCD is suspected based on the clinical features, immunohistochemistry is required to make a diagnosis.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 53 (6), 581-585, 2014
一般社団法人 日本内科学会