Food Restriction Causes Low Bone Strength and Microarchitectural Deterioration in Exercised Growing Male Rats

DOI Web Site PubMed 被引用文献3件 参考文献26件
  • HATTORI Satoshi
    Comprehensive Human Sciences, University of Tsukuba
  • PARK Jong-Hoon
    Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo Department of Physical Education, Konkuk University
  • AGATA Umon
    Comprehensive Human Sciences, University of Tsukuba
  • ODA Masaya
    Comprehensive Human Sciences, University of Tsukuba
  • HIGANO Michito
    Comprehensive Human Sciences, University of Tsukuba
  • AIKAWA Yuki
    Comprehensive Human Sciences, University of Tsukuba
  • AKIMOTO Takayuki
    Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo
  • NABEKURA Yoshiharu
    Comprehensive Human Sciences, University of Tsukuba Faculty of Health and Sport Sciences, University of Tsukuba
  • YAMATO Hideyuki
    Biomedical Research Laboratories, Kureha Co., Ltd.
  • EZAWA Ikuko
    Department of Food and Nutrition, Japan Women’s University
  • OMI Naomi
    Comprehensive Human Sciences, University of Tsukuba Faculty of Health and Sport Sciences, University of Tsukuba

この論文をさがす

抄録

The pathogenesis of bone disorders in young male athletes has not been well understood. We hypothesized that bone fragility is caused by low energy availability, due to insufficient food intake and excessive exercise energy expenditure in young male athletes. To examine this hypothesis, we investigated the influence of food restriction on bone strength and bone morphology in exercised growing male rats, using three-point bending test, dual-energy X-ray absormetry, and micro-computed tomography. Four-week-old male Sprague-Dawley rats were divided randomly into the following groups: the control (Con) group, exercise (Ex) group, food restriction (R) group, and food restriction plus exercise (REx) group after a 1-wk acclimatization period. Thirty-percent food restriction in the R and REx groups was carried out in comparison with that in the Con group. Voluntary running exercise was performed in the Ex and REx groups. The experimental period lasted 13 wk. At the endpoint of this experiment, the bone strength of the femurs and tibial BMD in the REx group were significantly lower than those in the Con group. Moreover, trabecular bone volume and cortical bone volume in the REx group were also significantly lower than those in the Con group. These findings indicate that food restriction causes low bone strength and microarchitectural deterioration in exercised growing male rats.

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (26)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ