Shufeng Jiedu Capsule protect against acute lung injury by suppressing the MAPK/NF-κB pathway

• Tao Zhengang

  Emergency Department, Zhongshan Hospital, Fudan University

• Gao Jingyan

  Department of Human Anatomy and Histo-embryology, Fudan University

• Zhang Guoliang

  Department of Infectious Diseases, Anhui Province Hospital of Traditional Chinese Medicine, Anhui University of Chinese Medicine

• Xue Mingming

  Emergency Department, Zhongshan Hospital, Fudan University

• Yang Weiqiang

  Emergency Department, Renji Hospital, Shanghai Jiaotong University

• Tong Caoyang

  Emergency Department, Zhongshan Hospital, Fudan University

• Yuan Ying

  Geriatrics Department, Zhongshan Hospital, Fudan University

抄録

This study sought to investigate the protective effect of an alternative medicine, Shufeng Jiedu Capsule, in acute lung injury and inflammation signaling pathways related to that action. Hematoxylin and eosin (HE) staining was used to observe pathological changes in rat lung tissue, arterial blood was subjected to blood gas analysis and lactic acid levels were determined, immunofluorescent staining for interleukin-1β (IL-1β) was performed, enzyme linked immunosorbent assay (ELISA) was used to detect biomarkers of the nuclear factor-κB (NF-κB) inflammation pathway including IL-1β and tumor necrosis factor α (TNF-α), biomarkers of the mitogen-activated protein kinase (MAPK) signal pathway including P-selectin, transforming growth factor β (TGF-β), keratinocyte-derived chemokine (KC), and C-Jun/AP-1 were measured, and real-time PCR was used to detect NF-κB mRNA. Results in rats with lipopolysaccharide-induced acute lung injury suggested that Shufeng Jiedu Capsule may increase the partial pressure of oxygen in lung tissue, decrease lactic acid levels, inhibit inflammatory factors such as IL-1β and TNF-α, and suppress the levels of P-selectin, TGF-β, KC, C-Jun/AP-1, and NF-κB mRNA. Thus, Shufeng Jiedu Capsule is a traditional medicine that may alleviate acute lung injury by suppressing the MAPK/NF-κB signaling pathway.

収録刊行物

• BioScience Trends

  BioScience Trends 8 (1), 45-51, 2014

  特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会

キーワード

• Acute lung injury
• Shufeng Jiedu Capsule
• dexamethasone
• rat model
• MAPK/NF-κB signaling pathway

詳細情報

• CRID: 1390001205736703360
• NII論文ID: 130003397283
• DOI: 10.5582/bst.8.45
• ISSN: 18817823
• ISSN: 18817815
• PubMed: 24647112
• Web Site: https://search.jamas.or.jp/link/ui/2015097815
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可