Changes in <i>Streptococcus pneumoniae</i> Serotypes in the Nasopharynx of Japanese Children after Inoculation with a Heptavalent Pneumococcal Conjugate Vaccine

• Ueno Masahiro

  Department of Pediatrics, Hasuda Issinkai Hospital Department of Environmental and Occupational Health, School of Medicine, Toho University

• Ishii Yoshikazu

  Department of Microbiology and Infectious Diseases, School of Medicine, Toho University

• Tateda Kazuhiro

  Department of Microbiology and Infectious Diseases, School of Medicine, Toho University

• Anahara Yoshiko

  Department of Bacteriology, Ageo Medical Laboratories, Inc.

• Ebata Akiko

  Department of Bacteriology, Ageo Medical Laboratories, Inc.

• Iida Masaei

  Department of Bacteriology, Ageo Medical Laboratories, Inc.

• Mizuno Fumie

  Department of Otorhinolaryngology, Hasuda Issinkai Hospital

• Inamura Seiko

  Yashio Ekimae Internal Medicine and Pediatric Clinic

• Takahata Kaori

  Department of Pediatrics, Tokyo Women's Medical University Medical Center East

• Suzuki Yoko

  Department of Pediatrics, Tokyo Women's Medical University Medical Center East

• Chang Bin

  Department of Bacteriology I, National Institute of Infectious Diseases

• Wada Akihito

  Department of Bacteriology I, National Institute of Infectious Diseases Yonaguni Medical Clinic

• Sugita Minoru

  Department of Environmental and Occupational Health, School of Medicine, Toho University

• Tanaka Taichiro

  Department of Environmental and Occupational Health, School of Medicine, Toho University

• Nishiwaki Yuji

  Department of Environmental and Occupational Health, School of Medicine, Toho University

Bibliographic Information

Other Title

• Changes in Streptococcus pneumoniae Serotypes in the Nasopharynx of Japanese Children after Inoculation with a Heptavalent Pneumococcal Conjugate Vaccine

Abstract

In this study, we prospectively investigated changes in Streptococcus pneumoniae serotypes among Japanese children after heptavalent pneumococcal conjugate vaccine (PCV7) inoculation. We acquired nasopharyngeal swabs from the children at each routine PCV7 inoculation and again at least 2 months after the last PCV7 inoculation. We defined 2 periods with regard to each culture: the inoculation period as “the period of pre- or incomplete vaccination” and post-inoculation as “the period of post- or completed vaccination.” The prevalence of vaccine-type (VT) pneumococci was significantly reduced from 9.5% in the inoculation-period cultures to 2.9% in the post-inoculation cultures (P < 0.01). There was no statistical difference in the prevalence of non-vaccine-type pneumococci between the inoculation-period and post-inoculation cultures (24.1% versus 23.4%). The protection of PCV7 against nasopharyngeal colonization was inferred from the decrease in VT carriage post-inoculation. The decrease in VT carriage may be conducive to reducing VT transmission within the study area.

Journal

• Japanese Journal of Infectious Diseases

  Japanese Journal of Infectious Diseases 67 (1), 40-43, 2014

  National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

Keywords

• <i>Streptococcus pneumoniae</i>, vaccine-type
• non vaccine-type
• heptavalent
• pneumococcal conjugate vaccine

Details

• CRID: 1390001206241181952
• NII Article ID: 130003399229
• NII Book ID: AA1132885X
• DOI: 10.7883/yoken.67.40
• ISSN: 18842836
• ISSN: 13446304
• NDL BIB ID: 025176447
• PubMed: 24451100
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025176447
• Web Site: https://search.jamas.or.jp/link/ui/2015062113
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed