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- 大村 裕
- Department of Physiology, Faculty of Medicine, Kyushu University Department of Biological Control Systems, National Institute for Physiological Sciences
抄録
GS and GR neurons are deeply involved in the feeding process. The importance of chemosensitive neurons in the regulation of feeding behavior, especially GS neurons in the hypothalamus, is supported by findings in acute rat, chronic rat, and chronic monkey. It is possible to correlate neuronal activity and application of such potentially important materials as glucose to eating related behavior of the monkey. Feeding control in the monkey is mediated in the LHA with its GS neurons that are similar to those found in the rat. These GS neurons are suppressed by NA and 2-DTA, and facilitated by 3-DPA. This agrees with the demonstration that the discharge rate of GS neurons in the monkey LHA increases preceding motions associated with food related tasks. A majority of the non GS neurons did not change in activity during the bar press period.<br>Since there are direct connections between the extra pyramidal and pyramidal systems and GS neurons, those GS neurons might also be involved in the initiation or regulation of movement related to feeding functions. It seems that the GS neurons in the LHA integrate information regarding these functions and thereby produce overall regulation of feeding behavior. It is also true that endogenous chemicals in the blood directly affect neurons in the NTS, DMV, and elements of vagal afferents in several peripheral organs. Thus, these chemicals affect neurons that in turn control other factors, to create positive or negative feedback loops. Many of the different loops have common, interdependent segments. Thus as shown in Fig. 1B there is a possible hierarchical arrangement of neuronal networks that process chemical information.<br>The prefrontal cortex and OBF are known to communicate actively with the hypothalamus and respond in synchronism with hypothalamic activity during feeding behavior. Thus, hypothalamic communication with association areas such as the OBF and prefrontal areas plus further integration of exogenous stimuli in these areas may lead to feeding-related decisions which then, in part, return to the visceral organs along paths parallel to those over which the afferent signals originally ascended and/or proceed to the motor system by way of the motor cortex. Finally, the fact that any of the CNS nuclei can have different functional effects on different visceral organs can be attributed, in part at least, to the networks through which they project.
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 35 (1), 1-19, 1985
一般社団法人 日本生理学会