Determination of 3.BETA.-hydroxylated bile acids in human serum and liver tissue.
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- NAGAKURA TAKATOMO
- The Third Department of Internal Medicine, Tohoku University School of Medicine
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- SUZUKI HIROSHI
- The Third Department of Internal Medicine, Tohoku University School of Medicine
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- MIYAZAKI YUTAKA
- The Third Department of Internal Medicine, Tohoku University School of Medicine
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- OTSUKI MASAO
- The Third Department of Internal Medicine, Tohoku University School of Medicine
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- GOTO JUNICHI
- Pharmaceutical Institute, Tohoku University
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- NAMBARA TOSHIO
- Pharmaceutical Institute, Tohoku University
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- TOYOTA TAKAYOSHI
- The Third Department of Internal Medicine, Tohoku University School of Medicine
抄録
NAGAKURA, T., SUZUKI, H., MIYAZAKI, Y., OTSUKI, M., GOTO, J., NAMBARA, T. and TOYOTA, T. Determination of 3β-Hydroxylated Bile Acids in Human Serum and Liver Tissue. Tohoku J. Exp. Med., 1989, 159 (2), 165-166-3β, 7α- Dihydroxy-5β-cholanoic acid (3β, 7α-diOH) was detected in serum of 3 patients with intrahepatic cholestasis. 3β, 7β-dihydroxy-5β-cholanoic acid (3β, 7β-diOH) appeared in serum of those patients after treatment with ursodeoxycholic acid (UDC). These bile acids were also detected in only unconjugated fractions of serum of another 7 patients with chronic liver diseases, but not in liver tissue of them. The liver does not seem to from these bile acids itself because they were absent in liver tissue.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 159 (2), 165-166, 1989
東北ジャーナル刊行会
