STRUCTURE-BIOLOGICAL ACTIVITIES RELATIONSHIPS AMONG LEUCOMYCINS AND THEIR DERIVATIVES

• OMURA SATOSHI

  The Kitasato Institute and Kitasato University

• KATAGIRI MICHIKO

  The Kitasato Institute and Kitasato University

• UMEZAWA IWAO

  The Kitasato Institute and Kitasato University

• KOMIYAMA KANKI

  The Kitasato Institute and Kitasato University

• MAEKAWA TOSE

  The Kitasato Institute and Kitasato University

• SEKIKAWA KENJI

  The Kitasato Institute and Kitasato University

• MATSUMAE AKIHIRO

  The Kitasato Institute and Kitasato University

• HATA TOJU

  The Kitasato Institute and Kitasato University

抄録

The relationship between chemical structure and biological activity of leucomycins and their derivatives was examined in vivo and in vitro. The biological activity of Fr-group was higher than that of Ac-group in vitro, but the latter showed higher blood level and lower toxicity than Fr-group. Lengthening of the carbon chain in the O-acyl group at C-4 in mycarose resulted in a marked increase in the biological activity in vitro, with the isovaleryl group having the highest activity. The aldehyde group in the lactone was related to antibiotic activity, but α, β, γ, δ-unsaturated alcohol system at C₉- to C₁₂-positions was not important.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 21 (9), 532-538, 1968

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390282679129507200
• NII論文ID: 130003408710
• NII論文ID: 40018688298
• NII書誌ID: AA0069330X
• DOI: 10.7164/antibiotics.21.532
• COI: 1:CAS:528:DyaF1MXhvVGqtQ%3D%3D
• ISSN: 18811469
• ISSN: 00218820
• NDL書誌ID: 8509954
• PubMed: 4975519
• Web Site: http://id.ndl.go.jp/bib/8509954
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8509954
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可