FR-31564, a new phosphonic acid antibiotic: Bacterial resistance and membrane permeability.

• KOJO HITOSHI

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• SHIGI YASUTAKA

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• NISHIDA MINORU

書誌事項

タイトル別名

• FR-31564 a New Phosphonic Acid Antibiot

抄録

Mutants which acquired resistance to FR-31564 were also resistant to fosfomycin and vice versa. Some exceptions to cross-resistance were found among clinical isolates of certain species. FR-31564 was found to be incorporated into bacterial cells more efficiently than fosfomycin although the extent of incorporation varied among species. In particular, the uptake rate of FR-31564 by a strain of Pseudomonas aeruginosa was ten times that of fosfomycin. The uptake rate of FR-31564 by both FR-31564- and fosfomycin-resistant Mutants was less than one-tenth of that by the parent strain. FR-31564 was scarcely inactivated in the culture broths of FR-31564-resistant strains.<br>All of the FR-31564-resistant mutants of P. aeruginosa came under the classification of strains lacking an L-α-glycerophosphate transport system.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 33 (1), 44-48, 1980

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390001204150313088
• NII論文ID: 130003409066
• NII論文ID: 40005314531
• NII書誌ID: AA0069330X
• DOI: 10.7164/antibiotics.33.44
• COI: 1:CAS:528:DyaL3cXht1amtLg%3D
• ISSN: 18811469
• ISSN: 00218820
• ISSN: http://id.crossref.org/issn/00218820
• NDL書誌ID: 2207057
• PubMed: 7378171
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I2207057
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可