Bacillaene, a Novel Inhibitor of Procaryotic Protein Synthesis Produced by Bacillus subtilis: Production, Taxonomy, Isolation, Physico-chemical Characterization and Biological Activity.
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- PATEL PRAMATHESH S.
- Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
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- HUANG STELLA
- Department of Analytical Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute
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- FISHER SUSAN
- Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
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- PIRNIK DOLORES
- Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
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- AKLONIS CAROL
- Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
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- DEAN LORETTA
- Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
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- MEYERS EDWARD
- Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
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- FERNANDES PRABHAVATHI
- Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
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- MAYERL FRIEDRICH
- Process and Research Development, Bristol-Myers Squibb Pharmaceutical Research Institute
書誌事項
- タイトル別名
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- Production, Taxonomy, Isolation, Physico-chemical Characterization and Biological Activity
抄録
Bacillaene, a novel polyene antibiotic, was discovered and isolated from fermentation broths of a strain of Bacillus subtilis. The novel antibiotic has a nominal molecular weight of 580 and an empirical formula of C35H48O7. Bacillaene is active against a broad spectrum of bacteria in agar-plate diffusion assays. Studies in vitro indicate that the antibiotic inhibits prokaryotic protein synthesis but not eukaryotic protein synthesis. Cell survival studies performed with strains of Escherichia coli indicate that the antibiotic is a bacteriostatic agent.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 48 (9), 997-1003, 1995
公益財団法人 日本感染症医薬品協会
