Effect of Solvents on Bioconversion of Penicillin G to Deacetoxycephalosporin G.

DOI PubMed 参考文献18件
  • GAO QIANG
    Biology Department, Massachusetts Institute of Technology Present address: Department of Chemical Engineering, University of Colorado
  • DEMAIN ARNOLD L.
    Biology Department, Massachusetts Institute of Technology

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The bioconversion of penicillin G, an inexpensive substrate, to the valuable intermediate for semi synthetic cephalosporin production, deacetoxycephalosporin G (DAOG), had been recently shown to be increased by eliminating agitation and adding decane. The present work examining other solvents shows that all alkanes tested are equivalent to decane in activity but that other solvents are either inhibitory or less active than alkanes. Optimum conditions of pH and temperature for the alkane system are not very different from the previously used aqueous system.

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