Effect of magnesium in cardioplegic solution upon hypothermic ischemic myocardial mitochondria.
書誌事項
- タイトル別名
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- Effect of Magnesium in Cardioplegic Sol
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抄録
Twelve anesthetized mongrel dogs were subjected to systemic hypothermia and potassium-induced cardioplegia for 60 minutes with or without magnesium-1-aspartate. The effect of magnesium was assessed by indices of mitochondrial oxidative phosphorylation. Cardiac arrest was induced by potassium (20 mEq per liter) (6 dogs) or potassium (20 mEq per liter)-magnesium (8 mM per liter). The heart was reperfused for ten minutes following arrest. Dogs were supported by standard cardiopulmonary bypass with hypothermia at 20°C of myocardial temperature. Mitochondria were isolated from the endocardium, the epicardium of the left ventricle and the ventricular septum. ADP : 0 ratio state 3 respiration were well maintained in both groups following 60 minutes of ischemic arrest and 10 minutes of reperfusion. Magnesium suppressed the non-phosphorylated oxygen consumption of mitochondria, therefore, respiratory control index was significantly enhanced in the group of potassium-magnesium-1-aspartate cardioplegia. These data suggest that magnesium protects functional capacity of mitochondrial phosphorylation in the myocardium from ischemia.
収録刊行物
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- JAPANESE CIRCULATION JOURNAL
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JAPANESE CIRCULATION JOURNAL 44 (2), 81-86, 1980
社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001206433656960
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- NII論文ID
- 130003420310
- 110002581691
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- NII書誌ID
- AN00191970
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- COI
- 1:CAS:528:DyaL3cXks1Wnu7c%3D
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- ISSN
- 13474839
- 00471828
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- NDL書誌ID
- 2210197
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- PubMed
- 7365986
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可