A Clinical Feature of Hyperlipidemia in Patients with Central Diabetes Insipidus.
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- TAKAHASHI-TEZUKA MARIKO
- Second Department of Internal Medicine, School of Medicine, Chiba University
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- KOBAYASHI JUNJI
- Second Department of Internal Medicine, School of Medicine, Chiba University
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- OTABE MASAKO
- Second Department of Internal Medicine, School of Medicine, Chiba University
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- HIRAI AIZAN
- Second Department of Internal Medicine, School of Medicine, Chiba University
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- TASHIRO JUN
- Second Department of Internal Medicine, School of Medicine, Chiba University
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- BUJO HIDEAKI
- Second Department of Internal Medicine, School of Medicine, Chiba University
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- MORISAKI NOBUHIRO
- Second Department of Internal Medicine, School of Medicine, Chiba University
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- SAITO YASUSHI
- Second Department of Internal Medicine, School of Medicine, Chiba University
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- YOSHIDA SHO
- Department of Internal Medicine Komagome Hospital
抄録
In this study, we analyzed plasma lipid and lipoprotein levels before and after treatment with 1-desamino-8-D-arginine vasopressin (DDAVP) in subjects with partial and complete central diabetes insipidus (DI) in order to determine how a shortage and supplement of this hormone affect plasma lipid metabolism. The subjects consisted of 6 patients with partial and 6 with complete central DI. After treatment with DDAVP through nasal cavity, plasma total cholesterol (TC) level did not decrease either in complete or partial form. Plasma triglyceride (TG) levels decreased from 306±175mg/dl to 198±91(35% decrease, p=0.027) in complete form, while TG did not change significantly in partial form. A detailed investigation of plasma lipoprotein metabolism during treatment with DDAVP was carried out in 3 of the 6 subjects with complete form of DI. Lipoprotein lipase activity and mass in post-heparin plasma from those three subjects tended to increase after treatment with DDAVP, along with the complete disappearance of an unusual lipoprotein between low density lipoprotein (LDL) and very low density lipoprotein (VLDL) as analyzed by polyacrylamide gel electrophoresis. These results suggest that the DDAVP treatment has a favorable effect on lipid and lipoprotein metabolism, especially triglyceride-rich lipoproteins, either directly or through modifying factors contributing to lipid metabolism.In this study, we analyzed plasma lipid and lipoprotein levels before and after treatment with 1-desamino-8-D-arginine vasopressin (DDAVP) in subjects with partial and complete central diabetes insipidus (DI) in order to determine how a shortage and supplement of this hormone affect plasma lipid metabolism. The subjects consisted of 6 patients with partial and 6 with complete central DI. After treatment with DDAVP through nasal cavity, plasma total cholesterol (TC) level did not decrease either in complete or partial form. Plasma triglyceride (TG) levels decreased from 306±175mg/dl to 198±91(35% decrease, p=0.027) in complete form, while TG did not change significantly in partial form. A detailed investigation of plasma lipoprotein metabolism during treatment with DDAVP was carried out in 3 of the 6 subjects with complete form of DI. Lipoprotein lipase activity and mass in post-heparin plasma from those three subjects tended to increase after treatment with DDAVP, along with the complete disappearance of an unusual lipoprotein between low density lipoprotein (LDL) and very low density lipoprotein (VLDL) as analyzed by polyacrylamide gel electrophoresis. These results suggest that the DDAVP treatment has a favorable effect on lipid and lipoprotein metabolism, especially triglyceride-rich lipoproteins, either directly or through modifying factors contributing to lipid metabolism.
収録刊行物
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- Endocrine Journal
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Endocrine Journal 47 (5), 557-562, 2000
一般社団法人 日本内分泌学会
