電気泳動法によって検出される遺伝標識の骨髄移植における挙動

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  • Behavior of genetic markers in recipients after bone marrow transplantation detected by electrophoresis.

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In this study on eight pairs of donors and recipients of bone marrow transplantation (BMT), broad range of gene markers at 16 gene loci, including 4 serum protein markers, 5 red cell enzyme markers detected by electrophoresis, and 7 salivary markers were evaluated before and 2, 4 and 6 months after BMT. As a result, 5 out of 16 gene loci of genetic markers in recipients were transformed into the donor type. BMT between family members may lead to transformation of gene markers, within a pattern compatible with family inheritance, and no genetic paradox will be found in later surveys of familial genetic relationships. However, in appearance of a phenotype incompatible with a blood relationship is possible after BMT from a non-blood-relative donor.

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