ＶＩＩＩ型コラーゲンの構造と生物学

DOI

書誌事項

タイトル別名
  • Structure and Biology of Type VIII Collagen.

抄録

Type VIII collagen was initially characterized as a biosynthetic product of bovine aortic endothelial cells in vitro and thus named Endothelial Collagen(EC). The protein has now been identified in avian and mammalian species as a product secreted by cultured corneal endothelial cells, keratinocytes, fibroblasts, astrocytoma and other tumor cells, and endothelial cells derived from several classes of blood vessels. In vivo, the distribution of type VIII collagen is restricted to specialized extracellular matrices such as meninges, periosteum, perichondrium, and Descemet's membrane of the cornea. It is also present in the subendothelium of large and small blood vessels and has been localized in capillary-like structures formed by sprouting cultures of endothelial cells. Data from protein and nucleotide sequencing have identified two distinct chains, termed α1 (VIII) and α2 (VIII); however, the assembly of these chains in the extracellular space is still poorly understood. Protein extracts from Descemet's membrane indicate that, in this tissue, type VIII collagen is a heterotrimer. Our understanding of the biological role of type VIII collagen is rather limited. Although type VIII collagen seems to perform a structural role in the Descemet's membrane, its temporally and spatially restricted expression during development suggests an involvement in tissue remodeling and differentiation.

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詳細情報 詳細情報について

  • CRID
    1390001204370227584
  • NII論文ID
    130003454732
  • DOI
    10.4052/tigg.4.188
  • ISSN
    18832113
    09157352
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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