EFFECT OF VASOPRESSIN ON PLASMA LIPIDS IN THE RAT

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  • 伊藤 真次
    Department of Physiology, Hokkaido University School of Medicine
  • 塚田 守雄
    Department of Physiology, Hokkaido University School of Medicine
  • 重茂 潔
    Department of Physiology, Hokkaido University School of Medicine

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Effects of neurohypophysial hormones on the plasma lipid concentrations were studied in the rat.<BR>1. The effect of AVP in decreasing plasma FFA level was less marked than that of LVP. The effect was significantly greater in cold-acclimated rats than in warm-acclimated ones.<BR>2. Plasma concentrations of esterified fatty acids and phospholipids were not affected by single injection of LVP and consecutive administrations of Pitressin tannate for 10 days. Similarly, glycerol concentration in the serum was not decreased after injection of vasopressin and oxytocin. Cholesterol was slightly reduced following successive injections of Pitressin tannate.<BR>3. Ultracentrifugal analysis of rat serum revealed two fractions of lipoproteins: Sf 3-8 and Sf 70-120. The Sf 70-120 fraction increased following vasopressin injection, while it decreased following oxytocin. The concentrations of Sf 3-8 fraction did not change after administration of the hormones.<BR>4. In neurohypophysectomized rats the low-density lipoprotein concentrations were in the normal ranges. The Sf 70-120 fraction disappeared after total hypophysectomy, although Sf 3-8 fraction remained unchanged.

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