EFFECTS OF TETRODOTOXIN ON RESPONSES OF THE FROG MUSCLE SPINDLE

• 伊藤 文雄

  Department of Physiology, School of Dentistry, Aichi-Gakuin University

抄録

Effects of tetrodotoxin on the spindle potential and the spike of isolated frog muscle spindle recorded using the paraffin gap method were studied.<BR>2×10^-8g/ml toxin first abolished the conductive spike and subsequently reduced the amplitude and the rate of rise of the abortive spike or the prepotential. 5×10^-8g/ml or more toxin erased the abortive spike and the prepotential without producing any significant effect on the spindle potential.<BR>It is assumed from the results that the prepotential may be the same as the abortive spike, and that the abortive spike may play a primary role in the initiation of the conductive spike as the prepotential when its amplitude is higher than a trigger level.<BR>The spindle potential was modified greatly depending on the sideward displacement of the axon in the paraffin pool during muscle stretch. Consequently, it seems that a part of the spindle potential may consist of an artifact.

収録刊行物

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 21 (3), 349-358, 1971

  一般社団法人　日本生理学会

キーワード

• General Medicine
• Physiology

詳細情報

• CRID: 1390001205042718208
• NII論文ID: 40018684295
• NII論文ID: 130003476368
• NII書誌ID: AA00691224
• DOI: 10.2170/jjphysiol.21.349
• COI: 1:CAS:528:DyaE38XlsVOrtA%3D%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL書誌ID: 8508262
• PubMed: 4261961
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8508262
• Web Site: https://search.jamas.or.jp/link/ui/1973080041
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可