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- PAULEV Poul-Erik
- Medical Physiology
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- THORBØLL Jens E.
- Medical Physiology
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- NIELSEN Ulla
- Medical Physiology
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- KRUSE Peter
- Medical Physiology
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- JORDAL ROBERT
- Department of Clinical Chemistry
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- BACH FLEMMING W.
- Department of Neurology, University of Copenhagen
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- FENGER Mogens
- Department of Clinical Chemistry
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- POKORSKI Mieczyslaw
- Polish Academy of Science, Medical Research Centre, Laboratory fo Neurophysiology
抄録
The purpose of this study was to evaluate the role of endogenous opiates in modulating physical performance during dynamic exercise in conscious man. The plasma concentration of β-endorphin (BEP) and of adrenocorticotropic hormone (ACTH) along with muscle pain (McGuill Pain Questionnaire) were assessed in 17 trained, male runners before and after running the longest possible distance within 12min (i.e., the Cooper test). Each runner participated twice in the test (double-blind cross-over design), with a 1-week interval-with or withoutan injection of the opiate antagonist naloxone (0.8mg i. v.). The average (SEM) distance reached was 3, 198 (45)m in the naloxone test and 3, 240 (38) m in the placebo test. The BEP increased significantly during the tests by a factor of 4.1 on naloxone and by 2.8 on placebo (from the normal resting averages of 1.7 and 2.1pmol/l, respectively). The ACTH also increased significantly by a factor of 2.0 on naloxone and 2.5 on placebo (from the normal resting averages of 19.3 and 16.8pmol/l, respectively). There were no significant differences between the naloxone and the placebo test with respect to the increments of BEP or ACTH by exercise. However, the perception of muscle pain was enhanced with naloxone. The increased perception of pain did not decrease the athletes ability to perform in terms of the distance run. We conclude that endogenous opiates are involved in the perception of pain associated with exhaustive exercise and may subserve psychological rather than physiological functions during exercise.
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 39 (1), 67-74, 1989
一般社団法人 日本生理学会
