乳牛におけるビタミンD3代謝に関する研究 : 血清中のビタミンD3代謝産物濃度からみたビタミンD3の代謝

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  • The Study on Vitamin D<SUB>3</SUB> Metabolism in Dairy Cows with Special Referenee to Serum Levels of Vitamin D<SUB>3</SUB> Metabolites
  • 乳牛におけるビタミソD<SUB>3</SUB>代謝に関する研究 : 血清中のビタミンD<SUB>3</SUB>代謝産物濃度からみたビタミンD<SUB>3</SUB>の代謝
  • ニュウギュウ ニ オケル ビタミン D3 タイシャ ニカンスルケンキュウ ケッ

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To study the metabolism of vitamin D3 in dairy cows, the serum levels of vitamin D3 metabolites were determined in healthy dairy cows raised on normal ration. Newborn, young and adult cows and vitamin D3 administrated adult cows were used in the experiment. Serum levels of 1α, 25-dihydroxyvitamin D3 and 24(R), 25-dihydroxyvitamin D3 in the newborn calves were higher compared with those in young and adult cows, whereas serum 25-hydroxyvitamin D3 levels was not changed in those three groups. On the other hand, daily administration of 10, 000 IU vitamin D3 to adult cows resulted in the increases of serum 25-hydroxyvitamin D3 and 24(R), 25-dihydroxyvitamin D3 levels. However, serum 1α, 25-dihydroxyvitamin D3 levels in those cows were not different from those in adult cows which did not receive vitamin D3. Whereas single administration of 150, 000 IU vitamin D3 showed a slight increase in serum 25-hydroxyvitamin D3 and 24(R), 25-dihydroxyvitamin D3, and a significant increase in serum 1α, 25-dihydroxyvitamin D3. Correlation between serum vitamin D3 metabolites and serum Ca, P or Mg concentration was not observed. However, correlation was observed between 24(R), 25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3. Serum 1α, 25-dihydroxyvitamin D3 was maintained relatively constant level, except for newborn calves and adult cows treated with 150, 000 IU vitamin D3. However, serum levels of 25-hydroxyvitamin D3 and 24(R), 25-dihydroxyvitamin D3 vatied in a certain degree directly proportional to intake of vitamin D3.

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