ビタミンD<SUB>2</SUB>およびコレステロール負荷ラット大動脈の初期病変の電顕所見

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  • Early ultrastructural changes of aorta in rats loaded with vitamine D2 and cholesterol.
  • ビタミンD2およびコレステロール負荷ラット大動脈の初期病変の電顕所見〔英文〕
  • ビタミン D2 オヨビ コレステロール フカ ラット ダイドウミャク ノ ショ

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Ultrastructural events in the early stage of the changes of the abdominal aorta in rats loaded with vitamin D2 and cholesterol were studied. The first appearing noticeable change was vesiculation in the intima which was attributable to the infiltration of blood plasma from the surface of endothelial cells. Then, intimal edema and deformation of the endothelial cells occurred. The subsequent course was characterized by degeneration of the inner and middle layers of the media accompanied with deposit of crystalline calcium salt. In the early stage of medial degeneration, crystallines of calcium salt first appeared within mitochondria of the smooth muscle cells. It was suggested that hypercalcemia due to vitamin D2 loading might play an important role in producing the early aortic lesions.

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