SHRにおける Vitamin D<SUB>2</SUB> 誘発動脈硬化症および抗Ca剤 diltiazem の効果

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タイトル別名
  • Vitamin D2-induced arteriosclerosis in spontaneously hypertensive rats and protection by diltiazem, a calcium antagonist.
  • SHRにおけるVitaminD2誘発動脈硬化症および抗Ca剤diltiazemの効果〔英文〕
  • SHR ニ オケル VitaminD2ユウハツ ドウミャク コウカショウ オヨ

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抄録

In male spontaneously hypertensive rats fed an atherogenic diet and treated with vitamin D2 (320, 000 I.U./kg/day) for 4 days, arteriosclerosis of Monckeberg type was produced in the aorta with multiple massive hemorrhage in the periaortic adipose and subdural tissues. The production of vascular changes and hemorrhages was inhibited by oral administration of a calcium antagonist, diltiazem (60 mg/kg-twice/day) for 7 days starting at the first day of vitamin D2 treatment.

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