イヌ乳腺腫瘍中のエストロジェンおよびプロジェステロン・レセプターとプロジェステロンの代謝

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  • Estrogen and progesterone receptors and progesterone metabolism in canine mammary tumours.
  • イヌ乳腺腫瘍中のエストロジェンおよびプロジェステロン・レセプターとプロジェステロンの代謝〔英文〕
  • イヌ ニュウセン シュヨウチュウ ノ エストロジェン オヨビ プロジェステロン

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Twenty-seven canine mammary tumours of varying histological types were examined for the presence of estrogen and progesterone receptors and aspects of [<14>C] -progesterone metabolism. Using dextran-coated charcoal method with the binding parameters of the reaction determined by Scatchard plots, a half of the 27 mammary tumours were shown to contain both receptors. The majority (69%) were benign tumours. This figure fell to 25% for estrogen receptor negative and/or progesterone receptor-negative tumours. After incubation of [<14>C]-progesterone with cell-free homogenates of mammary tumours and normal glands, 5α-pregnanedione, 17α-hydroxy-5α-pregnanedione, 5α-pregnanediols, and 5α-andro-stanedione were identified as the main metabolites. Although the enzyme activities relevant to the metabolism varied amoung the tissues examined, the most active enzyme demonstrated was 5α-reductase in both tissues. This enzyme activities were significantly greater in the estrogen receptor positive tumours than in the normal glands. These data indicate that some of canine mammary tumours may well be hormone-dependent and these possess active steroid metabolising enzymes.

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