マウス異種抗リンパ球抗体のマウスリンパ球に対する交差反応

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  • Cross-reactivities of mouse anti-xenogeneic lymphocyte antisera with mouse lymphocytes.
  • マウス異種抗リンパ球抗体のマウスリンパ球に対する交差反応〔英文〕
  • マウス イシュ コウ リンパキュウ コウタイ ノ マウス リンパキュウ ニ タ

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Cross-reactive antibodies which were reactive with mouse lymphocytes were detected in mouse antisera raised against lympocyte of the dog, chicken, bull frog or fish (Carassius carassius). All of the four xenoantisera crossreacted with the lymphocytes of A.TL(Ik), B10.BR(Ik), B10.A(Ia), B10.S(9R)(It4) and B10.D2(Ia), but not with those of A.TH(Is) and B10.S(Is). The xenoantisera raised against dog lymphocytes crossreacted with C57BL/6(Ib) lymphocytes, but the other three xenoantisera did not. Genetic mapping studies of the cross-reactive antibodies in the mouse indicated that the crossreaction of the four xenoantisera was attributable to antibodies to the Ia molecule similar to the I-E subregion gene product. In the case of A.TH anti-dog xenoantisera, antibodies to the Ia molecule similar to the I-A subregion gene product were also found. The cells cross-reactive with these four xenoantisera and Ig-positive B lymphocytes were enriched in the nylon-wool adherent fraction of B10.BR spleen cells, and depleted in the nylon-wool non-adherent fraction. These results showed that the xenoantisera crossreacted with the Ia antigens which are predominantly expressed on the surface of Ig+B lympocytes. These results confirmed the specificity of the crossreactions detected by A.TH(Is) anti-A.TL(Ik) alloantiserum, and further indicated that the crossreactive genes are the homologues of the mouse I-E subregion gene in the chicken, frog and fish, and of the I-A and I-E subregion genes in the dog.

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