老齢ラットの自然発生性神経根神経症における坐骨神経の電子顕微鏡的観察

DOI 日本農学文献記事索引 Web Site Web Site PubMed

書誌事項

タイトル別名
  • Electronmicroscopy of sciatic nerves in aging rats with spontaneous radiculoneuropathy.
  • 老齢ラットの自然発生性神経根神経症における坐骨神経の電子顕微鏡的観察〔英文〕
  • ロウレイ ラット ノ シゼン ハッセイセイ シンケイコン シンケイショウ ニ

この論文をさがす

抄録

The sciatic nerves of fourteen 104- to 135-week-old rats with spontaneous radiculoneuropathy were examined by light and electron microscopy. The most conspicuous changes were the nerve fiber degeneration indicative of wallerian degeneration and regeneration. Along with these changes, shrinking axons with disproportionally thicker myelin sheaths could sometimes be observed in large myelinated nerve fibers. In these myelinated fibers, there were also demyelinative changes characterized by wide distention of myelin sheaths with shrinkage of axons which are the most prominent changes in the spinal nerve roots in the radiculoneuropathy. Among the nerve fibers showing these demyelinative changes, axonal degradation following shrinkage of axons could be detected in several fibers. Our findings may suggest that shrinking axons in the spinal nerve roots cause axonal degradation and subsequent destruction of nerve fibers in the more distal portion of the peripheral nervous system in aging rats with radiculoneuropathy.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ