犬糸状虫症における血清ハプトグロビン濃度

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  • Serum haptoglobin levels in canine dirofilariasis.
  • 犬糸状虫症における血清ハプトグロビン濃度〔英文〕
  • イヌ シジョウチュウショウ ニ オケル ケッセイ ハプトグロビン ノウド エイ

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Serum haptoglobin (Hp) concentration was determined as a hemoglobin binding capacity in normal dogs and dogs with dirofilariasis. The serum Hp level in 13 normal dogs was 114.8±31.5 (S.D.) mg/dl. In 33 dogs with mild dirofilariasis, serum Hp concentration ranged widely from 0 to 349.5mg/dl with a mean of 75.1±151.4mg/dl. In this group, the case which showed respiratory abnormalities had a higher serum Hp level. The cases in which urine or renal hemosiderin was detected showed low serum Hp concentrations. In 17 dogs with chronic serious dirofilariasis, the serum Hp level was 33.7±59.8mg/dl. In this group, only 2 cases had a slightly higher serum Hp concentration. Serum Hp level of 0mg/dl was found in 8 cases (47.1%). In 21 dogs with dirofilarial hemoglobinuria (caval syndrome), the serum Hp concentration ranged from 9.9 to 135.0mg/dl with a mean of 48.2±29.5mg/dl. The serum Hp level in this group was higher than in the serious group. The plasma hemoglobin concentration was higher than the serum Hp concentration in all cases in the hemoglobinuria group. From these findings, the intravascular hemolysis should exist not only in the hemoglobinuria group but also in the mild and serious groups.

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