ラット胎仔の除脳あるいは下垂体除去による甲状腺濾胞細胞の微細構造の変化

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  • Ultrastructural changes in the thyroid follicular cells following encephalectomy or hypophysectomy in fetal rats.
  • ラット胎仔の除脳あるいは下垂体除去による甲状腺濾胞細胞の微細構造の変化〔英文〕
  • ラット タイシ ノ ジョ ノウ アルイハ カスイタイ ジョキョ ニ ヨル コウ

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The ontogeny of the thyroid-stimulating activity of the pituitary gland associated with or dissociated from the hypothalamic control was studied in fetal rats based on electron microscopic observations of the thyroid follicular cells. The day following overnight mating was regarded as day 0 of gestation. Fetal hypophysectomy or encephalectomy (pituitary gland left intact) was performed on day 16, 17, 18 or 19, and operated fetuses were autopsied 2 days later and compared with intact littermate controls. In hypophysectomized fetuses, the weight of thyroid gland was reduced, the area ratio of "nucleus/cell" was increased and that of "rER/cytoplasm" was decreased, as compared with controls in all age groups. These changes were accompanied by shortening of microvilli on the apical surface of follicular cells, flattening of cells and shrinkage of the rER. In encephalectomized fetuses, no changes were found in all the parameters tested as compared with the controls. These electron microscopical observations support the view that the pituitary-thyroid axis in fetal rats develops independently of hypothalamic control.

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