弱毒マウス肝炎ウイルスMHV-2-CC株による胸腺欠損ヌードマウスの活動性肝炎に対する組換型インターロイキン2の効果

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  • Effects of interleukin-2 on active hepatitis in athymic nude mice due to low-virulence mouse hepatitis virus.
  • 弱毒マウス肝炎ウイルスMHV-2-CC株による胸腺欠損ヌードマウスの活動性肝炎に対する組換型インターロイキン2の効果〔英文〕
  • ジャクドク マウス カンエン ウイルス MHV-2-CC カブ ニ ヨル キョ

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The effects of a recombinant interleukin-2 (rIL-2) on active hepatitis due to low virulence mouse hepatitis virus, MHV-2-CC, in athymic nude mice, were studied. Athymic nude mice were inoculated intraperitoneally with 6×105 PFU of the virus and given daily with 0.1, 1 and 10μg of rIL-2. The nude mice treated with 1μg of rIL-2 showed virus titers 1 log lower than those of untreated mice, through Days 7 to 21 of postinoculation. Liver lesions in mice treated with 1 or 10μg of rIL-2 were characterized by multiple round and circumscribed necrotizing foci without inflammatory cells, whereas inflammatory reactions were noticeable in necrotizing lesions of non-treated controls. At the periphery of the lesions of rIL-2 treated mice there were many degenerated hepatocytes being positive for viral antigen surrounded by mononuclear cells, some of which were positive with asialo-GM1.

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