犬糸状虫予防薬ミルベマイシンの臨床応用 : 投薬後の病理学的所見

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  • Clinical application of milbemycin D as a prophylactic agent against Dirofilaria immitis infection in dogs: Pathological findings following administration.
  • 犬糸状虫予防薬ミルベマイシンの臨床応用--投薬後の病理学的所見〔英文〕
  • イヌ シジョウチュウ ヨボウヤク ミルベマイシン ノ リンショウ オウヨウ ト

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Pathological findings following milbemycin D (Milbe) administration were examined in 54 dogs. No significant changes were seen in the uninfected group (9 dogs). In microfilaria (mf)-positive group (22 dogs), yellowish-brown spots in the liver, splenomegaly, and reddish-brown spots in the lungs were seen on macroscopic examination, and inflammatory reactions phagocytizing the microfilariae by macrophage were noted in the liver, lungs, spleen and heart on the microscopie examination. These lesions were observed with almost the same frequcncy and severity in the shock-like (7 dogs) and caval syndrome (22 dogs) groups. Howcver, they showed a lower rate and slighter degree in the mf-negative group (11 dogs). To examine the correlation of hepatic lesions and microfilariae, hepatic biopsics and calculations of circulating microfilariae were performed with time in 3 dogs. The number of circulating microfilariae was markedly reduced by 6 hr after administration. Microfilariae in the sinusoid increased in number at 3 hr after administration, neutrophils adhered to microfilariae at 6 hr, macrophages infiltrated around microfilariae and focal necroses containing microfilariae were observed in parenchyma at 9 hr, and macrophage masses were formed at 12 hr.

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