Therapeutic effect of isoprothiolane on bovine fat necrosis.

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  • 牛の脂肪壊死症に対するisoprothiolaneの治療効果
  • 牛の脂肪壊死症に対するisoprothiolaneの治療効果〔英文〕
  • ウシ ノ シボウ エシショウ ニ タイスル isoprothiolane ノ

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Abstract

Bovine fat necrosis is frequently observed in Japanese Black cattle. In an attempt to treat fat necrosis, we found remarkable therapeutic effect of isoprothiolane, an analogous compound of malotilate, which is applied to hepato-cirrhosis of man. Fifty-one Japanese Black cattle with subclinical fat necrosis were examined by rectal palpation. They were given orally a daily dose of 50 mg/kg body weight of isoprothiolane for 8 weeks. Twelve weeks after initiation of medication, separated or disintegrated, softened and diminished masses of necrotic tissue were noticed or even disappeared in 35 cattle (68.5%). Of 22 medicated cattle examined one year after the initiation of medication, 21 cattle (99.5%) showed a remarkable reduction of foci in size or disappearance of the necrotic tissue. Decrease of free fatty acid and triglyceride and slight increase of phospholipid and total cholesterol in sera were recognized after treatment. These results indicate that isoprothiolane is effective for clinical use in treating bovine fat necrosis.

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