Babesia rodhaini超音波処理抗原と Corynebacterium parvum死菌体の免疫接種部位に関する検討

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  • Studies on route of immunization with a mixture of killed parasites and adjuvants against Babesia rodhaini infection in mice.
  • Babesia rodhaini超音波処理抗原とCorynebacterium parvum死菌体の免疫接種部位に関する検討〔英文〕
  • Babesia rodhaini チョウオンパ ショリ コウゲン ト Cory

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A series of experiments were undertaken to determine the most effective route of immunization with a mixture of killed Babesia rodhaini antigen (S antigen) and formalin-fixed Corynebacterium parvum (Propionibacterium acnes) bacterin (CPB) against challenge infection with B. rodhaini 3 weeks later. The mice pretreated with S antigen and CPB mixture intraperitoneally, but not intramuscularly, were significantly resistant to intraperitoneal (IP) or intravenous (IV) challenge with 106 organisms. The survival rates were 70.0 (IP challenge) and 60.0% (IV challenge) respectively. Fairly protective activities were equally produced in mice intravenously pretreated with S antigen and CPB with survival rates of 60.0% against IV challenge, but 30% against IP. These results indicated that the IP injection of S antigen and CPB mixture is desirable route for immunization against subsequent IP or IV challenge with B. rodhaini. On the other hand, lower protective effect was reconfirmed in the mice treated with S antigen and Freund's Complete adjuvant, regardless of immunization routes in the additional experiment. The survival rates were 33.3, 14.3 and 11.8% in the intraperitoneally, intramuscularly and subcutaneouly-treated mice respectively against IP challenge with 106 organisms.

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