遺伝性高 Na, K-ATPase犬赤血球のメトヘモグロビン形成および還元
書誌事項
- タイトル別名
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- Methemoglobin formation and reduction in canine erythrocytes with inherited high Na, K-ATPase activity.
- 遺伝性高Na,K-ATPase犬赤血球のメトヘモグロビン形成および還元〔英文〕
- イデンセイ コウ Na K ATPase イヌ セッケッキュウ ノ メトヘモグ
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抄録
Methemoglobin formation and reduction in canine erythrocytes with inherited high Na, K-ATPase activity (HK cells) were compared with those in normal canine cells (LK cells). Nitrite-induced methemoglobin formation in hemoglobin solutions indicated that the hemoglobin from HK cells was oxidized at essentially the same rate as that of LK cells. However, methemoglobin formation in HK cells was slower, due to the inhibition by high glutathione (GSH) concentration. Methemoglobin reduction was allowed to take place on nitrite-treated and washed erythrocytes in a glucose medium and was reduced more rapidly in HK cells than in LK cells. During the reduction, the amounts of lactate and pyruvate increased more rapidly in HK cells, indicating enhanced glycolysis in HK cells. It is thus evident that the hemoglobin of HK cells is more securely protected from nitrite-induced oxidation by the GSH presence in great excess and by the increase in glycolysis.
収録刊行物
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- 日本獸醫學雜誌(The Japanese Journal of Veterinary Science)
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日本獸醫學雜誌(The Japanese Journal of Veterinary Science) 51 (6), 1185-1192, 1989
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681398683520
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- NII論文ID
- 110003918124
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- NII書誌ID
- AN00191788
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- COI
- 1:CAS:528:DyaK3cXhsFKis7k%3D
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- ISSN
- 18811442
- 00215295
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- NDL書誌ID
- 3262185
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- PubMed
- 2557475
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
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- PubMed
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- 使用不可