書誌事項
- タイトル別名
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- Increased erythrophagocytic activity of macrophages in dogs with Babesia gibsoni infection.
- Babesia gibsoni感染貧血犬におけるマクロファージの赤血球貪食能の亢進〔英文〕
- Babesia gibsoni カンセン ヒンケツ イヌ ニ オケル マクロフ
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抄録
To elucidate the mechanism of anemia caused by Babesia gibsoni infection in dogs, the erythrophagocytic activity of macrophages in infected dogs was investigated in vitro. In the present study, macrophages obtained from peripheral blood (PB-macrophages) and bone marrow (BM-macrophages) of splenectomized dogs with chronic B. gibsoni infection were examined. The BM-macrophages in the splenectomized dogs with chronic babesiosis exhibited an increased erythrophagocytic activity compared with those from splenectomized, non-infected dogs. In the infected dogs, erythrophagocytic activities of macrophages against both auto- and iso-erythorcytes from normal dogs were almost the same. Administration of an anti-protozoal drug, diminazene diaceturate, resulted in a decrease of the erythrophagocytic activity of BM-macrophages associated with an increase of the hematocrit value in splenectomized dogs with chronic babesiosis. In splenectomized dogs with acute babesiosis, erythrophagocytic activity of BM-macrophages was also elevated. Such a phenomenon was not, however, observed in splenectomized dogs with onion-induced hemolytic anemia. These results suggest that the erythrophagocytic ability of macrophages in the infected dogs might be accelerated by parasites per se through an unknown machanism, resulting in severe anemia in spite of low parasitemia.
収録刊行物
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- 日本獸醫學雜誌(The Japanese Journal of Veterinary Science)
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日本獸醫學雜誌(The Japanese Journal of Veterinary Science) 52 (2), 321-327, 1990
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681399566336
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- NII論文ID
- 110003918194
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- NII書誌ID
- AN00191788
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- COI
- 1:STN:280:By%2BB2s7ksFI%3D
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- ISSN
- 18811442
- 00215295
- http://id.crossref.org/issn/00215295
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- NDL書誌ID
- 3671133
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- PubMed
- 2348598
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可