Reactivity of Neutralizing Antibodies with Different Specificities to H Particles of Poliovirus

• URASAWA Tomoko

  Department of Hygiene and Epidemiology, Sapporo Medical College

• URASAWA Shozo

• TANIGUCHI Koki

抄録

In order to elucidate the antigenic structure of poliovirus, the reactivity of antibody produced with H antigenic particles of Mahoney strain (polio type 1) was investigated.<BR>Injection of H particles of Mahoney strain into rabbits yielded neutralizing antibody as well as CF-N and CF-H antibodies. This result coincided with the report by Hinuma and coworkers. Neutralization tests with inhibitor resistant Mahoney mutants revealed that the neutralizing antibody produced with H particles was of HN31 type, one of the five different kinds of polio neutralizing antibodies reported previously (14). Absorption experiments with H particles on different neutralizing antibodies and analysis of antibody eluted by acid dissociation from antiserum-treated H particles also showed that the HN31 type antibody specifically combined with H particles ofMahoney strain.<BR>Since the H particle of poliovirus is known to be deficient in VP4, these results seems to indicate that the HN31 type antibody reacts with a structural part (s) of poliovirus other than VP4.

収録刊行物

• MICROBIOLOGY and IMMUNOLOGY

  MICROBIOLOGY and IMMUNOLOGY 23 (7), 651-657, 1979

  Center For Academic Publications Japan

詳細情報

• CRID: 1573950402849057920
• NII論文ID: 130003482829
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00187534251?from=CiNii
• 本文言語コード: en
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