Nonspecific Stimulation of Antibacterial Resistance by a Synthetic Thymic Factor (FTS) in Mice

• MATSUMOTO Takao

  Department of Microbiology, Jichi Medical School

• NAKANO Masayasu

抄録

Treatment of mice with 0.01-1 μg of a synthetic serum thymic factor (FTS) significantly increased their resistance to lethal doses (1-5 × 10⁶ organisms) of Salmonella typhimurium LT2 (LT2). At least seven injections of FTS were necessary for induction of resistance, since the effects of one to three injections were variable. FTS additively potentiated the protective immunity to LT2 induced by immunization with an avirulent mutant of LT2, irrespective of the structural components of the cell wall lipopolysaccharides of the mutants, which are basically correlated with their immunogenicity and virulence. Activated macrophages may have a direct role in the induction of host resistance, since peritoneal macrophages from FTS-treated DBA/2 mice which are resistant to the doses of LT2 used could by themselves retard bacterial growth in vitro, whereas those from CBA/N mice which are relatively susceptible to LT2 did not inhibit bacterial growth without intervention of FTS-treated syngeneic T cells.

収録刊行物

• MICROBIOLOGY and IMMUNOLOGY

  MICROBIOLOGY and IMMUNOLOGY 24 (12), 1185-1197, 1980

  Center For Academic Publications Japan

詳細情報

• CRID: 1571135653082002944
• NII論文ID: 130003482902
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00168089244?from=CiNii
• 本文言語コード: en
• データソース種別:
  • CiNii Articles