Effect of <i>Clostridium perfringens</i> Beta Toxin on Blood Pressure of Rats
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- SAKURAI Jun
- Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- FUJII Yoshio
- Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- DEZAKI Keiko
- Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- ENDO Koichi
- Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
抄録
Guanethidine treatment or adrenal medullectomy significantly inhibited the elevation in blood pressure induced by Clostridium perfringens beta toxin, and the combination of the two drastically reduced the pressure rise, to less than 19% of that in control rats. When rats were pretreated with tetrodotoxin or hexamethonium, the toxin-evoked rise was significantly inhibited. Elevation in blood pressure induced by the toxin in spinal rats tended to be less than that in control rats. When investigated by a microscopical technique, arteriolar constriction in the mesenteric vasculature was observed after the blood pressure elevation induced by the toxin reached a maximum. Blood flow in the skin decreased with an increase in blood pressure following intravenous injection of the toxin. It is concluded that beta toxin acts on the autonomic nervous system and produces arterial constriction.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 28 (1), 23-31, 1984
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1571417128058703872
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- NII論文ID
- 130003482966
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles