Development of DTH Skin Reaction to HBsAg in Individuals Immunized with HB Vaccine

  • KASHIWAGI Seizaburo
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • NAGAFUCHI Seiho
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • INOUE Takatoshi
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • HAYASHI Shin
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • TAKESHITA Shigemori
    Department of Pathology, Faculty of Medicine, Kyushu University
  • IMAYAMA Shuhei
    Department of Dermatology, Faculty of Medicine, Kyushu University

抄録

To examine the temporal relationship between the DTH skin reaction to HBsAg and antibody response to HBsAg, serial skin tests for HBsAg were carried out on seven individuals immunized with HB vaccine.<br>All cases developed both a skin reaction and antibody response. In many cases, the DTH skin reaction appeared four weeks before the antibody response. These data suggest that DTH skin reaction may be a more sensitive method than humoral antibody assessment for monitoring the success of vaccination.

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