Reverse Effect of Gram-Positive Bacteria <i>vs</i>. Gram-Negative Bacteria on Adjuvant-Induced Arthritis in Germfree Rats
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- KOHASHI Osamu
- Research Institute for Diseases of the Chest, Faculty of Medicine
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- KOHASHI Yukiko
- Research Institute for Diseases of the Chest, Faculty of Medicine
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- TAKAHASHI Tokutaro
- Yakult Central Institute for Microbiological Research
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- OZAWA Atsushi
- Department of Microbiology, Tokai University, School of Medicine
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- SHIGEMATSU Nobuaki
- Research Institute for Diseases of the Chest, Faculty of Medicine
Bibliographic Information
- Other Title
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- Reverse Effect of Gram‐Positive Bacteria <i>vs</i>. Gram‐Negative Bacteria on Adjuvant‐Induced Arthritis in Germfree Rats
Abstract
Germfree (GF) F344 rats developed severe adjuvant-induced arthritis with a 100% incidence after a single intradermal injection of heat-killed Mycobacterium bovis (BCG). Specific pathogene-free (SPF) rats developed less severe arthritis with a lower incidence. The rats colonized with Escherichia coli or Bacteroides developed mild disease comparable to that in SPF rats. The rats colonized with Bifidobacterium, Propionibacterium acnes, Lactobacillus casei, L. fermentum, L. murini, and L. acidophilus developed more severe disease than that in GF rats. Furthermore, the rats colonized with a mixture of E. coli and the above lactobacilli developed very mild disease similar to that in SPF rats. These results suggest that (1) gram-negative bacteria, such as E. coli and Bacteroides, may suppress the disease, possibly through their lipopolysaccharides, and may be responsible for the lower susceptibility of SPF rats; (2) gram-positive bacteria, such as Bifidobacterium, P. acnes, and lactobacilli, may enhance the disease, possibly through their peptidoglycans; and (3) E. coli may play a dominant role in modulating the development of adjuvant-induced arthritis.
Journal
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 29 (6), 487-497, 1985
Center For Academic Publications Japan
