Effect of <i>Bordetella</i> Heat-Labile Toxin on Perfused Lung Preparations of Guinea Pigs
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- ENDOH Masahiko
- Department of Microbiology, School of Pharmaceutical Sciences, Kitasato University
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- NAGAI Masaaki
- Department of Microbiology, School of Pharmaceutical Sciences, Kitasato University
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- NAKASE Yasukiyo
- Department of Microbiology, School of Pharmaceutical Sciences, Kitasato University
抄録
In vitro effects of the Bordetella HLT on the isolated perfused lung and some other tissue preparations from guinea pigs were examined. When HLT (30 to 300MNDs/ml) was administered, an increase of the perfusion pressure was induced in the perfused lungs, indicating vasoconstriction. When 100 or 300MNDs/ml of HLT was given, the pressure increase appeared after a lag period of 3.5 to 4min, reached a maximum within 8 to 13min, and then slowly decreased by 60 to 80% 25min after exposure. In calcium-free medium, the pressure increase dur to HLT did not occur, but these HLT-treated lungs manifested an increase without any lag period immediately after the calcium-free medium was replaced by normal medium containing calcium. No difference in the response of the perfused lungs to histamine was observed before and after exposure to HLT. The arterial strip did not respond to HLT, but after predigestion with a collagenase and elastase solution the contractive response to 100MNDs/ml of HLT appeared with a lag period of 1min. HLT had no effect on the pharmacological responses of the isolated atria, deferent canal or intestinal preparations, or on the ciliary movement of cultured tracheal rings.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 30 (12), 1239-1246, 1986
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1572261552987760768
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- NII論文ID
- 130003483183
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles