Induction of Antibodies against Newcastle Disease Virus with Syngeneic Anti-Idiotype Antibodies in Mice

J-STAGE
  • TANAKA Masayuki
    Division of Veterinary Microbiology, Kyoto Biken Laboratories
  • SASAKI Norimasa
    Division of Veterinary Microbiology, Kyoto Biken Laboratories
  • SETO Akira
    Department of Microbiology, Faculty of Medicine, Kyoto University

抄録

Anti-idiotype antibodies were induced by injecting BALB/c mice with syngeneic antibody against the hemagglutinin of Newcastle disease virus (NDV). These anti-idiotype antibodies were purified and injected into syngeneic mice. Anti-anti-idiotype sera thus prepared contained antibodies against the hemagglutinin of NDV. This NDV-mouse experimental system might provide a good experimental model for investigation of basic problems of idiotype vaccine.

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