Temperature-Sensitive Growth Mutants as Live Vaccines against Experimental Murine Salmonellosis

• OHTA Michio

  Department of Bacteriology, Nagoya University School of Medicine

• KIDO Nobuo

  Department of Bacteriology, Nagoya University School of Medicine

• FUJII Yasuaki

  Department of Bacteriology, Nagoya University School of Medicine

• ARAKAWA Yoshichika

  Department of Bacteriology, Nagoya University School of Medicine

• KOMATSU Takayuki

  Department of Bacteriology, Nagoya University School of Medicine

• KATO Nobuo

  Department of Bacteriology, Nagoya University School of Medicine

抄録

Temperature-sensitive growth mutants of Salmonella enteritidis, NUB 209 and NUB 323, characterized as protein synthesis mutants, were unable to proliferate at 37C and lost the parent's virulence. In mice, these mutants conferred high levels of protection as live vaccines. Although the vaccination effect of NUB 323 was not so good as that of NUB 209, NUB 323 was preferred as a safer live vaccine because this mutant was completely avirulent and no back mutation appeared.

収録刊行物

• MICROBIOLOGY and IMMUNOLOGY

  MICROBIOLOGY and IMMUNOLOGY 31 (12), 1259-1265, 1987

  Center For Academic Publications Japan

詳細情報

• CRID: 1572824502941394304
• NII論文ID: 130003483315
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00172596462?from=CiNii
• 本文言語コード: en
• データソース種別:
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