Immune Response to <i>Toxoplasma gondii</i>

J-STAGE
  • YANO Akihiko
    Laboratory of Immunology, Department of Infectious Diseases and Parasitology, Shinshu University School of Medicine
  • AOSAI Fumie
    Laboratory of Immunology, Department of Infectious Diseases and Parasitology, Shinshu University School of Medicine
  • YAMASHITA Keizo
    Laboratory of Immunology, Department of Infectious Diseases and Parasitology, Shinshu University School of Medicine
  • SUGANE Kazuo
    Laboratory of Immunology, Department of Infectious Diseases and Parasitology, Shinshu University School of Medicine
  • HAYASHI Shigeo
    The National Institute of Health

Abstract

Ultrasonicated Toxoplasma gondii (RH strain) tachyzoite extract was chromatographed on Sephadex G-200, and one main peak (93, 000M.W.) and three small peaks (>160, 000M.W., 110, 000M.W., and 20, 000M.W.) were eluted. Toxoplasma-specific proliferative T cell responses of peripheral blood leukocytes (PBL) from a patient with acute toxoplasmosis caused by accidental injection of tachyzoites of the protozoa were sequentially examined by using these fractioned antigens. As early as one week after the accidental injection of the protozoa, significant proliferative responses of PBL could be detected. The reaction of proliferative T cells was observed occurring mainly with Fr. II antigen. Then T cells began to respond to Fr. I and III in addition to Fr. II 3 weeks after the injection. Thus, expansion of antigen specificity in Toxoplasma-specific T cell responses was observed at the initial stage of acquired acute toxoplasmosis.

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