Response of Ligated Rabbit Ileal Loop to <i>Clostridium perfringens</i> Type C Strains and Their Toxic Filtrates

J-STAGE
  • YAMAGISHI Takayoshi
    Department of Bacteriology and Immunology, School of Medicine, Toyama Medical and Pharmaceutical University
  • GYOBU Yotaku
    Toyama Institute of Health
  • SAKAMOTO Kenichi
    Department of Bacteriology and Immunology, School of Medicine, Toyama Medical and Pharmaceutical University
  • ISHISAKA Shintaro
    Department of Bacteriology and Immunology, School of Medicine, Toyama Medical and Pharmaceutical University
  • SAITO Kimie
    Department of Bacteriology and Immunology, School of Medicine, Toyama Medical and Pharmaceutical University
  • MORINAGA Shinichi
    Department of Bacteriology and Immunology, School of Medicine, Toyama Medical and Pharmaceutical University
  • KATSUDA Shogo
    First Department of Pathology, School of Medicine
  • UMEI Tamiko
    Para-Medical School, Kanazawa University
  • KONISHI Kenichi
    Department of Bacteriology and Immunology, School of Medicine, Toyama Medical and Pharmaceutical University

抄録

The vegetative cells and toxic filtrates of Clostridium perfringens type C strains were injected into ligated rabbit Real loops and the responses were observed. Out of 12 strains examined, 2 strains showed positive reaction in this test, when the vegetative cells were injected. One of these 2 strains was an enterotoxigenic and beta-toxigenic and the other was beta- and delta-toxigenic but not enterotoxigenic. Culture filtrates containing beta or delta toxin also showed fluid accumulation in the rabbit ileal loop. Histological findings of loops injected with culture filtrates containing beta toxin showed separated and effaced villi, hemorrhage in the mucosa, engorged vessels, inflammatory cell infiltration, and hyperplasia of the lymphoid tissue.

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