Inhibitory Activity of (E)-5-(2-Bromovinyl)-2'-Deoxyuridine on the Salmonid Herpesviruses, Oncorhynchus masou Virus (OMV) and Herpesvirus salmonis

• Kimura, Takahisa

• Nishizawa, Toyohiko

• Yoshimizu, Mamoru

• De Clercq, Erik

抄録

The highly potent and selective anti-herpesvirus agent, (E)-5-(2-bromovinyl)-2'deoxyuridine (BVdU), was examined for its inhibitory effect on the salmonid herpesviruses Oncorhynchus masou virus (OMV) and Herpesvirus salmonis (H. salmonis). Minimum inhibitory concentrations (MIC) of BVdU for OMV and H. salmonis were 1.25 and 3.0 μg/ml, respectively; these values were equal to or higher than those obtained for acyclovir or cytarabin. OMV DNA polymerase activity was reduced in a dose-dependent fashion by BVdU 5'-triphosphate (BVdUTP) within the concentration range of 3 to 30 μm. However, BVdUTP could also be substituted for the natural substrate, TTP, in the OMV DNA polymerase assay. It is postulated that the inhibitory action of BVdU on the salmonid herpesviruses is more or less similar to that on other herpesviruses and resides with respect to the inhibition of the virus DNA polymerase activity as well as incorporation of BVdU into the viral DNA.

収録刊行物

• Microbiology and Immunology

  Microbiology and Immunology 32 (1), 57-65, 1988

  Center for Academic Publications Japan

詳細情報

• CRID: 1050845763930976000
• NII論文ID: 130003483393
• HANDLE: 2115/39476
• ISSN: 03855600
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles