Enhancement of Host Resistance against <i>Listeria</i> Infection by <i>Lactobacillus casei</i>
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- SATO Katsumasa
- Department of Microbiology and Immunology, Shimane Medical University
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- SAITO Hajime
- Department of Microbiology and Immunology, Shimane Medical University
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- TOMIOKA Haruaki
- Department of Microbiology and Immunology, Shimane Medical University
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- YOKOKURA Teruo
- Yakult Central Institute for Microbiology Research
抄録
Cell wall, cytoplasm, polysaccharide, and peptidoglycan fractions prepared from Lactobacillus casei, L. plantarum, and L. acidophilus were examined for their efficacies to enhance resistance of host mice against Listeria monocytogenes infection. Intraperitoneal injections of those cellular fractions of L. casei led to elicitation of inflammatory cells in the peritoneal cavity and the efficacy was highest in the case of peptidoglycan. Macrophage ratio in the resultant peritoneal exudate cells was also highest in mice given peptidoglycan. Macrophages induced with cell wall fraction of L. casei showed the most potent phorbol myristate acetate (PMA)-triggered respiratory burst (chemiluminescence and O2- production determined on the basis of nitroblue tetrazolium reduction) followed by those elicited with peptidoglycan. All the macrophages induced with cell wall of L. casei (two strains) and L. acidophilus enhanced O2- production in response to PMA but L. plantarum did not enhance O2--producing ability in such a manner. The L. casei-cell wall also enhanced in vitro listericidal activity of mouse peritoneal macrophages, but such an activity was not noted in the case of L. acdiophilus-cell wall. When mice were intravenously given the cellular fractions 7 or 13 days before L. monocytogenes infection, cell wall fractions of L. casei caused the most potent protective activity. A weak protective activity was also found in peptidoglycan of L. casei. Therefore, the protective action of L. casei against L. monocytogenes infection in host mice may be attributed to cell wall compounds and partially to the peptidoglycan moiety.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 32 (12), 1189-1200, 1988
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1573668927872235520
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- NII論文ID
- 130003483411
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles