Depression of T Cell-Mediated Immunity and Enhancement of Autoantibody Production by Natural Infection with Microorganisms in Spontaneously Hypertensive Rats (SHR)
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- TAKEICHI Noritoshi
- Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine
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- HAMADA Jun-ichi
- Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine
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- TAKIMOTO Masato
- Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine
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- FUJIWARA Kosaku
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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- KOBAYASHI Hiroshi
- Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine
抄録
We studied the effects of breeding conditions on the development of immunological abnormalities in spontaneously hypertensive rats (SHR) with congenital T cell depression. The depression of T cell functions, the production of natural thymocytotoxic autoantibody (NTA), and the development of polyarteritis nodosa were more evident in SHR reared under a conventional (CV) environment than in specific-pathogen-free (SPF) SHR bred in a semi-barrier system. Enhancement of these immunologic abnormalities was also observed by the conventionalization of SPF-SHR. A high frequency of antibodies to mouse hepatitis virus (MHV), Sendai virus, and Mycoplasma pulmonis was detected in CV rat sera, whereas no antibodies were detected in SPF-SHR. The experimental infection of Sendai virus induced the enhancement of T cell depression and of NTA production in SPF-SHR. We interpret these results to mean that the natural infection of microorganisms causes an acceleration of immunologic abnormalities in SHR reared in a CV environment.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 32 (12), 1235-1244, 1988
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1571135653081852672
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- NII論文ID
- 130003483415
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles