Monoclonal Antibodies to O4 Antigen of <i>Vibrio parahaemolyticus</i>

J-STAGE
  • OGAWA Setsuko
    Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
  • KOSHIKAWA Tomihiko
    Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
  • WATABE Kazuhito
    Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
  • YAMAZOE Mari
    Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
  • TORII Mitsuo
    Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
  • SAKATO Nobuo
    Department of Immunology, The Research Institute for Microbial Diseases, Osaka University
  • AZUMA Takachika
    Department of Immunology, The Research Institute for Microbial Diseases, Osaka University
  • FUJIO Hajime
    Department of Immunology, The Research Institute for Microbial Diseases, Osaka University

抄録

Four monoclonal antibodies were prepared against O4 antigen of Vibrio parahaemolyticus. All the antibodies were shown to be specific for O4 antigen by agglutination with heat-killed O-cells of the organism and precipitation with LPS preparations. The inhibition experiments of the precipitations with various sugars and oligosaccharides suggested that the combining sites of these hybridoma antibodies were directed to an antigenic determinant structure containing →3 and →6 linked D-glucose, D-galactose, and N-acetyl-D-galactosamine.

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