T Cell-Mediated Cytotoxicity against Dengue-Infected Target Cells

J-STAGE
  • PANG Tikki
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya
  • DEVI Shamala
    Department of Genetics and Cellular Biology, Faculty of Science, University of Malaya
  • BLANDEN Robert V.
    Department of Microbiology, John Curtin School of Medical Research, Australian National University
  • LAM Sai Kit
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya

抄録

A cytotoxic T lymphocyte (CTL) response to dengue virus-infected target cells is described. Effector cells were generated in an in vitro secondary culture and appeared to be T cells possessing both the Lyt 1.1 and Lyt 2.1 surface antigens. A stronger CTL response was noted with the H-2k haplotype compared to H-2d, and H-2 compatibility was required between CTL and target cells. CTL generated showed some cross-reactivity with target cells infected with Japanese encephalitis virus (JEV), another flavivirus, but not with target cells infected with an alphavirus, Sindbis. The significance and importance of these findings are discussed.

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