Effects of the Antiserum against a Fraction Enriched in Scrapie-Associated Fibrils on the Scrapie Incubation Period in Mice

J-STAGE
  • ITO Masako
    Department of Veterinary Public Health, School of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • SHINAGAWA Morikazu
    Department of Veterinary Public Health, School of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • DOI Satoshi
    Department of Veterinary Public Health, School of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • SASAKI Satoshi
    Department of Veterinary Physiology, School of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • ISOMURA Hiroshi
    Department of Veterinary Public Health, School of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • TAKAHASHI Kaname
    Department of Veterinary Microbiology, School of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • GOTO Hitoshi
    Department of Veterinary Microbiology, School of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • SATO Gihei
    Department of Veterinary Public Health, School of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine

抄録

An antiserum against a fraction enriched for scrapie-associated fibrils (SAF), was examined for its effects on scrapie incubation period by inoculating mice either intraperitoneally or intracerebrally with various dilutions of the serum mixed with scrapie-infected mouse brain homogenate. After intraperitoneal inoculation the mean time of the incubation period increased with increasing concentrations of the antiserum in a statistically significant fashion, when the serum dilutions were made with phosphate-buffered saline. After intracerebral inoculation, however, there were no statistically significant differences between the control group and any of the antiserum-groups. When the antiserum dilutions were made with pre-immune serum, the mice inoculated intraperitoneally also showed no significant differences between the two groups. These results indicate that the specific antibodies to SAF have no effect on the scrapie infectivity.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ