Endotoxic Properties of Chemically Synthesized Lipid A Analogs
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- YOSHIDA Masao
- School of Medicine, Iwate Medical University
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- HIRATA Michimasa
- School of Medicine, Iwate Medical University
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- INADA Katsuya
- School of Medicine, Iwate Medical University
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- TSUNODA Nobuko
- School of Medicine, Iwate Medical University
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- KIRIKAE Teruo
- School of Medicine, Iwate Medical University
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- ONODERA Tsuyoshi
- School of Medicine, Iwate Medical University
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- ISHIKAWA Yoshihito
- School of Dentistry, Iwate Medical University
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- SASAKI Osamu
- School of Dentistry, Iwate Medical University
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- SHIBA Tetsuo
- Faculty of Science, Osaka University
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- KUSUMOTO Shoichi
- Faculty of Science, Osaka University
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- GALANOS Chris
- Max Planck Institut fÜr Immunbiologie
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- LÜDERITZ Otto
- Max Planck Institut fÜr Immunbiologie
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- KONDO Seiichi
- School of Pharmaceutical Sciences, Josai University
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- HISATSUNE Kazuhito
- School of Pharmaceutical Sciences, Josai University
抄録
Biological activities of two groups of synthesized lipid A analogs, the counterpart of biosynthetic precursor, Lehmann's Ia type, 406, and E. coli lipid A type, 506, as well as their non-phosphorylated, and mono-phosphorylated analogs were investigated. The activities employed included four bone marrow cell reactions in mice, mice skin reaction, leukocytes migration in rabbits' cornea, and hemagglutination. Compound 406 and 506 elicited bone marrow reactions in mice and hemagglutination of mouse RBC, although 406 failed to elicit hemorrhage and necrosis also in mice skin. Compound 406 did not elicit corneal reaction in rabbits. The results suggest that for elicitation of this reaction and mice skin reaction, acyloxyacyl structure is required. Cytotoxicity and thromboplastin production of four bone marrow reactions had been reported by us to be endotoxic reactions, since these had not been elicited by peptidoglycan of Lactobacillus and Staphylococcus (1981) and 300 series synthetized analogs (1984) which did not have endotoxic structures. From these results, it seems that these two marrow reactions and hemagglutination require, as does the limulus test, the lipid A part structure as is present in 406.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 33 (10), 797-810, 1989
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1573950402849070464
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- NII論文ID
- 130003483521
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles